Diclofenac belongs to the group of non-steroidal agents with marked analgesic and anti-inflammatory properties. It is indicated in case of severe, acute pain including :
acute joint inflammations (arthritis), gout attacks. chronic joint inflammations, especially when several joints are affected (chronic polyarthritis/rheumatoid arthritis) Bechterew's disease (ankylosing spondylitis) and other inflammatory rheumatoid disorders of the spine. Acute inflammatory condition of degenerative joint or spinal disorders (arthroses and spondylarthroses) Soft tissue rheumatisms. Painful swelling or inflammation after injuries or minor surgeries.

Diclofenac may inhibit labour pains and increase the tendency to bleeding. LOFNAC Rectal may only be used after careful consideration by the Physician of the benefits and risks, for: induceable porphyrias, the first six months of pregnancy (agreement by the Physician is absolutely necessary) Sometimes local reactions can occur including irritations, bloody mucous secretion or painful stools.

LOFNAC may increase plasma concentrations of Lithium and Digoxin if these substances are administered simultaneously. It may diminish the effect of dehydrating and blood pressure reducing agents (diuretics and antihypertonics). Concomitant treatment with Potassium-saving diuretics may be associated with increased Potassium levels in the serum. Concomitant administration of glucocorticoids or other anti-inflammatory agents increase the risk of gastro-intestinal bleeding. If LOFNAC is given within 24 hours before or after the administration of Methotrexate, the concentration of Methotrexate and its toxic effect may increase. The simultaneous intake of Acetyl-salicylic Acid reduces the serum concentration of Diclofenac.