| |
| Gvither® 20 / 40 / FORTE Injection |
| Presentation |
Gvither 80mg/ml,
ampoule. Clear glass ampoules containing Artermether 80 mg in 1 ml. solution
The solution is pale
yellow & sterile. |
| Pharmacodynamics |
Artemether, and its
derivatives act essentially as blood schizonticides. The presence of the
endoperoxide bridge
appears to be essential for anti-malaria activity: generation of singlet oxygen
and formation of free
radicals, inhibition of protein synthesis as the basic mechanism of action is
suggested in studies
which showed morphological changes in ribosomes as well as in the
endoplasmic reticulum. |
| Pharmacokinetics |
Artemether, when
injected through in route is rapidly absorbed reaching Cmax withing 2-3 hours.
It is metabolised in
the liver to the demethylated derivative Dihydroartemisinin The elimination is
rapid, with a T 1/2 of 4 hours. Dihydroartemisinin has T 1/2 of more than l0 hours. |
| Indications |
Gvither is indicated
for the treatment of malaria caused by all forms of plasmodium including
severe malaria caused
by multiple drug resistant strains of P. falciparum. |
| Side Effects |
At the therapeutic
dose (700 mg) there are virtually no side effects There are reports on
laboratory
abnormalities i.e., a
decrease in reticulocytes count, an increase in transaminase and ECG changes
(Sinus Bradycardia}.
However, these are transient. At high doses, transient abdominal pain,
diarrhoea and
tinnitus can occur. |
| Contra-Indication |
| Pregnancy, unless the
doctor considers it essential as in the case of Cerebral malaria. |
| Dosage and Adminstration |
|
Day - 1 |
Day - 2 |
Day - 3 |
Day - 4 |
Day - 5 |
| Adults |
160 mg
(2 Amps) |
80 mg
(1 Amp) |
80 mg
(1 Amp) |
80 mg
(1 Amp) |
80 mg
(1 Amp) |
| Children |
4 0 mg/kg
body wt. |
2 0 mg/kg
body wt. |
2 0 mg/kg
body wt. |
2.0 mg/kg
body wt. |
2.0 mg/kg
body wt. |
|
| Precautions |
| In Cerebral malaria
and complicated malaria, general supporting therapy may be required. |
| Conservation |
| Gvither 80mg injection
should be protected from light and stored at room temperature. If stored
for long periods in
the cold, precipitation may occur which may clear on storage at room
temperature If not,
the contents of the ampoule should be discarded Do not store below room
temperature |
| Presentation |
Gvither
80mg.Kit pack : Contains 1 sterile Artemether Injection Ampoule with
Sterilised
disposable 2 ml Syringe and sterile needle
BRISTAL PACK 2 X 5 X 1 ml. Ampoule blisters
are packed in a carton. |
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