| |
| Alaxin Tablet - Dihydroartemisinin Tablets |
| Active Ingredient. |
| 8 hydro - 3,6,9, - trimethyl 1-3,12 - epoxy-12 H-prano - [4,3,-J]-1,2-
benzodioxopine - 10(3H) - ol
C15 H24 O5 (mol. wt - 284.36) |
| Composition |
Each coated tablet contains :
Dihydroartemisinin 60 mg
Excipients q.s.
Colour Permitted. |
| Pharmacology |
Powerful plasmodicide of malaria parasite agamete which quickly controls symptoms. Highly
effective against all types of malaria including multi-drug resistant malaria. It has high safety
and low toxicity. Reproduction toxicology, increase foetal absorption during pregnancy in mice.
No mutation effect observed. |
| Pharmacokinetics |
Oral administration of dihydroartemisinin. Absorption is rapid and complete, and the active
agent takes effect promptly. Human Pharmacokinetics parameters :
Oral dosage 2 mg/kg, Tmax = 1.33h, Cmax=0.71mg/ml, T1/2=1.57h,
Special features :
absorption rapidly, distribution extensively, excretion and metabolism quickly. |
| Indication |
| All types of malaria including severe malaria, cerebral malaria and multi-drug resistant malaria. |
| Side Effect |
| No side effects have been reported on clinical dosage. However, very few cases of temporary
reticulocyte subsidence have been noted. |
| Contraindications |
| The drug should be used with care in early period of pregnant woman. |
| Storage |
| Preserve in well-closed, light-resistant containers. Store in a cool place. |
| Packing Form |
| Tablets in vesicular plates. |
| Adminstration and dosage for adults and children |
| Age Group |
Day - 1 |
Day - 2 |
Day - 3 |
Day - 4 |
Day - 5 |
Day - 6 |
Day - 7 |
Total Dose Mg. |
| Adults |
120 |
60 |
60 |
60 |
60 |
60 |
60 |
480 |
| Child yrs. 11-15 |
90 |
45 |
45 |
45 |
45 |
45 |
45 |
360 |
| 7-10 |
60 |
30 |
30 |
30 |
30 |
30 |
30 |
240 |
| 4-6 |
40 |
20 |
20 |
20 |
20 |
20 |
20 |
160 |
| 1-3 |
30 |
15 |
15 |
15 |
15 |
15 |
15 |
120 |
|
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