| |
| Alaxin 20 / 40 / 80 Suppository |
| Pharmacology |
A powerful plasmodicide, which controls symptoms rapidly. It is highly effective against all types of malaria including multi-drug resistant malaria. It has a high safety profile and low toxicity. In reproduction toxicology, there was an increased fetal absorption during pregnancy in mice. No mutation effects were observed. |
| Pharmacokinetics |
After rectal administration, Dihydroartemisinin absorption is rapid and complete, and the active agent takes effect promptly. Pharmacokinetic parameters by rectal route are: Tmax = 1.68 + 0.33hr; Cmax = 0.42µg/ml, T1/2 = 1.57 + 0.46hr. Special features include rapid absorption, extensive distribution, quick excretion and metabolism. |
| Indications |
| For the treatment malaria due to Plasmodium falciparum, Plasmodium vivax and Plasmodium malariae, as well as in complicated malaria especially for those who cannot take oral medication. The effacy of Dihydroartemisinin suppository is obviously superior to that of IV Quinine and other non-artemisinin oral anti-malarials. |
| Side Effects |
reatment with Alaxin suppository appears to be generally well tolerated. There have been few reports of mild gastrointestinal disturbance, dizziness, tinnitus, neutropenia and elevated liver enzyme values. |
| Storage |
Preserve in well-closed, light resistant containers. Store in a cool place. |
| Packing |
Alaxin 20 Suppository: Strip of 8 Suppositories
Alaxin 40 Suppository: Strip of 8 Suppositories
Alaxin 80 Suppository: Strip of 8 Suppositories |
| Dosage Recommendations |
Adults: Dosage recommendation for multi-drug resistant P. falciparum malaria and non-complicated malaria is by rectally, 80mg bid (2 suppositories) on the first day followed by 80mg daily for the next six days. This dosage
scheme consisting of 640mg total dose of Dihydroartemisinin has been found to prevent recrudescence.
Children: The recommended dosage using the 40mg suppository is by rectally,40mg bid (2 suppositories) on the first day followed by 40mg daily for the next six days. This is suitable for children from ages 7 to 12. Children below seven years require 20mg bid for the first day followed by 20mg suppositories daily for the next six days. |
| Description |
| White or pale yellow suppositories made by incorporation of Dihydroartemisinin in soluble base. |
| Caution |
Diarrhoea may lead to poor absorption of the drug. The drug may be used in the second and third trimester but with caution in the first. However, there are no reports of Teratogenicity with its use in the first trimester of pregnancy. |
| Validity |
| 3 years from the date of manufacture. |
Back 
